Is Cholesterol the Key to Understanding Alzheimer’s?

This article presents a brief analysis of the following study presented in the Journal of the American Medical Association:

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4,and the Risk of Late-Onset Alzheimer Disease in African Americans


While this article is definitely too complex for the average reader, it does further highlight something I have discussed in the past.  There is new evidence that genes involving lipid/cholesterol transport are linked to increased Alzheimer’s disease risk.  It is my opinion that the amyloid and other protein deposits that accumulate in the brains of Alzheimer’s patients is involved in metabolic pathways shared by the cholesterol transport system.  HDL cholesterol is implicated in this pathway process and now this recent article implicates a transporter system called ATP-Cassette binding transporter. This system is involved in cholesterol transport as well.  There is evidence that using statins in at risk Alzheimer’s patients is associated with lower rates of clinical disease.

In a previous post , I discussed an interesting mouse experiment showing that increasing Apo E (associated with HDL and VLDL cholesterol metabolism) resulted in the mice clearing the protein associated with Alzhiemer’s and that these animals bred as Alzheimer’s models resolved their memory and abnormal smell function.  This suggests that if we can alter these pathways in humans we might actually cure/reverse Alzhiemer’s even if clinically present.

Onward and upward with studying this hypothesis!!!

Raymond Kordonowy, MD

About thedoctorsreport

Dr. Kordonowy is board certified by the American Board of Internal Medicine and has been in private practice since 1993. His group practice is in Fort Myers, Florida. His website is: He earned his degree from the University of Kansas School of Medicine in Kansas City, Kansas and completed his residency as Chief Resident at Orlando Regional Hospital System. As Chief Resident, Dr. Kordonowy was recognized as the Outstanding Resident by the American College of Physicians. He is a member of the American Medical Association, American College of Physicians, and the American Society of Internal Medicine. In December 2005, Dr. Kordonowy became Board Certified in the new field of Clinical Lipidology by the American Board of Clinical Lipidology. Lipidology is the specialty of diagnosis and management of cholesterol and triglyceride metabolism disorders. Cardiovascular disease risk assessment is also part of this specialty. He now serves as president of the Independent Physicians Association of Lee County. He is active in the Lee County Medical Society, the Florida Medical Society , the Florida Lipid Foundation, National Lipid Association and the American Medical Association.
This entry was posted in Medical Journal Briefs and tagged , , , , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s